Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elastin as a matrikine.

Laurent Duca1, Nicolas Floquet, Alain J P Alix

  • 1Université de Reims Champagne Ardenne, IFR53 Biomolécules, UFR Sciences Exactes et Naturelles, FRE CNRS 2534, Moulin de la Housse, BP 1039, 51687 Reims Cedex 2, France.

Critical Reviews in Oncology/Hematology
|March 24, 2004
PubMed
Summary

Elastin peptides, fragments of elastin, promote cell growth and enzyme release, suggesting a role in tumor progression. These matrikines, also called elastokines, can mimic each other's effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Development of novel anti-Kv 11.1 antibody-conjugated PEG-TiO<sub>2</sub> nanoparticles for targeting pancreatic ductal adenocarcinoma cells.

Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology·2026
Same author

Assembly and remodeling of collagen and elastic fibers in pathophysiology: Proteases have the final cut.

The FEBS journal·2026
Same author

Binding of the elastin peptide VGVAPG and lactose to the human elastin binding protein.

Journal of structural biology·2026
Same author

Minoxidil and nebivolol restore aortic elastic fiber homeostasis in diabetic mice via potassium channel activation.

Frontiers in physiology·2025
Same author

Unveiling G-Protein-Coupled Receptor Conformational Dynamics via Metadynamics Simulations and Markov State Models.

Journal of chemical information and modeling·2025
Same author

Xanthohumol Sensitizes Melanoma Cells to Vemurafenib by Lowering Membrane Cholesterol and Increasing Membrane Fluidity.

International journal of molecular sciences·2025

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Elastin peptides are degradation products of elastin, an extracellular matrix protein.
  • These peptides exhibit chemotactic, cell cycle-promoting, and enzyme-releasing activities.
  • Their presence in tissues suggests a potential role in tumor progression.

Purpose of the Study:

  • To review the biological activities of elastin peptides.
  • To emphasize their potential role in cancer.
  • To discuss their receptor and signaling pathways.

Main Methods:

  • Literature review of elastin peptide functions.
  • Analysis of elastin peptide-receptor interactions.
  • Discussion of elastokines and morpho-elastokines.

Related Experiment Videos

Main Results:

  • Elastin peptides act as matrikines, influencing cell behavior.
  • They can induce proteolytic enzyme release from stromal and cancer cells.
  • A specific elastin complex receptor and its signaling are involved.

Conclusions:

  • Elastin peptides (elastokines) contribute to tumor progression.
  • The elastin receptor exhibits structural selectivity.
  • Morpho-elastokines mimic the effects of bioactive elastin peptides.