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Related Experiment Videos

Malignancy in autoimmune diseases.

L J Kinlen1

  • 1CRC Cancer Epidemiology Group, University of Oxford, Radcliffe Infirmary, UK.

Journal of Autoimmunity
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Patients with rheumatoid arthritis (RA) have a higher risk of non-Hodgkin's lymphoma (NHL), especially after immunosuppressive therapy. This suggests impaired immunosurveillance may promote malignancy in autoimmune diseases.

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Area of Science:

  • Immunology
  • Oncology
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) is a well-studied autoimmune disease linked to malignancy.
  • Elevated risks of non-Hodgkin's lymphoma (NHL) are observed in RA patients, particularly after immunosuppressive therapy.
  • Similar trends are noted in Sjögren's syndrome, suggesting a role for immune system defects.

Purpose of the Study:

  • To explore the relationship between autoimmune disorders, immunosuppression, and cancer risk.
  • To investigate the hypothesis of impaired immunosurveillance in the development of malignancy.
  • To examine the types of cancers associated with immune impairment.

Main Methods:

  • Review of published cohort studies on rheumatoid arthritis and malignancy.
  • Analysis of cancer incidence in patients with and without immunosuppressive therapy.

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  • Comparison of cancer risks in different immune-impaired states.

    • Main Results:

    • RA patients show a 9.7-fold increased risk of NHL with immunosuppressive therapy and a 2.5-fold increase without it.
    • Immunosuppressive therapy is linked to increased risks of specific cancers: NHL, skin cancer, Kaposi's sarcoma, and cervical carcinoma.
    • Immune impairment, including AIDS, is associated with increased NHL rates, often correlating with viral etiologies.

    Conclusions:

    • Impaired immunosurveillance, a defect in the immune system, may promote malignancy.
    • Immunosurveillance appears most effective against virus-associated neoplasms.
    • A viral etiology might underlie the increased NHL risk in autoimmune disorders, especially post-immunosuppression.