Einstein's Institute for Aging Research: collaborative and programmatic approaches in the search for successful aging

While aging research has been progressing rapidly recently, the involvement of multiple organs and systems in the aging process has hampered a comprehensive assessment of some of aging's basic features. In response to this problem, the Institute for Aging Research at Einstein did not emerge out of the traditional geriatric programs, but through enhanced collaborations between basic and clinical scientists who had successful careers in the research of a specific organ or system. The strength of the Center derives from three specific programs focused on a specific area of aging research. The programs focus on the Biology of Aging, Genetics of Aging and the Aging Brain. Each programmatic area is characterized by collaboration between basic and clinical scientists. In addition to addressing the traditional questions about the mechanisms of involution, the programs also examine the mechanisms for exceptional and healthy longevity. The mechanisms favoring longevity are being examined in models of caloric restriction (biological nutrient sensing pathways), in human centenarians (longevity genes), and in longitudinal studies identifying humans who maintain excellent cognitive function (protection from Alzheimer's). Each programmatic area is enhanced by common research core laboratory and by the creation of a scientific training program for new investigators. In addition to the investigators involved in the program project, the Institute for Aging Research includes other investigators with funded aging research who participate in journal clubs, seminars, and in specific collaborations. We suggest that this Institute serve as a model that gerontologists at other institutions should consider as they evaluate opportunities for collaborative, multi-disciplinary approaches to enhance aging research.