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Association of progesterone receptor polymorphism with recurrent abortions

Andreas Schweikert¹, Thomas Rau, Alexander Berkholz

¹Division of Gynecological Endocrinology & Reproductive Medicine, Department of Obstetrics and Gynecology, University of Erlangen-Nürnberg, Universitätsstrasse 21-23, 91054 Erlangen, Germany.

European Journal of Obstetrics, Gynecology, and Reproductive Biology

|March 24, 2004

Abstract

Objective:

The current study sought for polymorphisms within the progesterone receptor (PR) gene. Allele and genotype frequencies of patients with repeated abortions were compared to a control group.

Design:

All exons of the PR of 42 women with repeated abortions and 40 controls were screened for single nucleotide polymorphisms (SNP). Determination of the DNA-sequences was performed.

Results:

Three SNPs were detected (exon 1: G1031C Ser344Thr; exon 4: G1978T Leu660Val, exon 5: C2310T His770His). These SNPs are linked. The more frequent wildtype (*1) allele and the rarer (*2) allele were found in the control group and in the study group at different frequencies (control group: *1/*1: 78%, *1/*2: 22%, *2/*2: 0%; patient group: *1/*1: 50%, *1/*2: 43%, *2/*2: 7%). The genotypes distributions differed significantly from each other (P=0.019, chi2=7.879).

Conclusions:

The data suggest that the rarer PR allele may be associated with an increased likelihood of repeated miscarriages contributing to its multi-factorial causes.

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