Related Experiment Video
Updated: Aug 25, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
Renal oncocytomas with rearrangements involving 11q13 contain breakpoints near CCND1
Stefanie Zanssen1, Bastian Gunawan, Laszlo Fuzesi
1Department of Neurology, Columbia University College of Physicians and Surgeons, Room P&S 4-431, 630 West 168th Street, New York, NY 10032, USA.
Abstract:
Oncocytomas are typically benign epithelial tumors whose predominant feature is a massive accumulation of mitochondria in the cytoplasm. With the goal of identifying genes controlling mitochondrial proliferation, we studied three oncocytomas belonging to the cytogenetic subgroup with 11q13 rearrangements. Fluorescence in situ hybridization using bacterial artificial chromosome (BAC) clones showed that the 11q13 breakpoints in all three tumors were near the CCND1 (previously BCL1) gene and did not disrupt any other known gene. The rearrangement in one tumor consisted of a segmental duplication that included 11q13, suggesting that known mitochondrially targeted genes immediately distal to CCND1 may be involved in oncocytic proliferation.
Related Concept Videos
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Non-LTR Retrotransposons
