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Antigen-receptor degeneracy and immunological paradigms
Irun R Cohen1, Uri Hershberg, Sorin Solomon
1The Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100 Israel. irun.cohen@weizmann.ac.il
Molecular Immunology
|March 24, 2004
Abstract:
This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones.