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Updated: Aug 25, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Clinical results with imatinib in chronic myeloid leukaemia
Lucy C Crossman1, Stephen O'Brien
1School of Clinical & Laboratory Sciences, University of Newcastle, Newcastle NE2 2HH, UK.
Abstract:
Since its introduction 5 years ago, imatinib mesylate has shown remarkable efficacy in treating patients with chronic myeloid leukaemia. Here we shall review the clinical results seen with imatinib at all stages of the disease, current views on the best way to monitor patients' responses and potential ways of predicting response to treatment. We shall also briefly cover the reasons why quiescent stem cells pose a theoretical threat to successful treatment.
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