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Determinants of plasma leptin concentration in postmenopausal women
Esther M Brooks-Asplund1, Carrie E Tupper, Jane M Daun
1Noll Physiological Research Center, Pennsylvania State University, University Park, PA 16802, USA.
Abstract:
This investigation examined the influence of hormone replacement therapy on plasma leptin concentrations in postmenopausal women and sought to determine if a relationship existed between plasma leptin, the thermoregulatory cytokine interleukin-1 (IL-1), and basal body temperature. Twenty-two women (54-71 years of age) were studied: eight were not taking hormone replacement, seven took oral estrogen only, and seven took oral estrogen plus progestin. Morning oral temperature, plasma leptin concentration, and mononuclear cell secretion of IL-1beta, IL-1 receptor antagonist (IL-1Ra), and soluble IL-1 receptor type II (sIL-1RII) were measured. Plasma leptin concentrations were not affected by hormone replacement therapy, but were inversely related to years since menopause (R = -0.48, P = 0.02) and were proportional to IL-1 activity (the balance of IL-1beta/IL-1Ra secretion, R = 0.69, P = 0.001). Moreover, morning oral temperature was positively related to plasma leptin (P = 0.03), after stratifying by progestin intake. These results support the concept that basal body temperature is regulated by a network of endocrine and immune mediators that are significantly influenced by age.
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