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Disappearing calvarium in Gorham disease: MR imaging characteristics with pathologic correlation
Chung-Ping Lo1, Cheng-Yu Chen, Shy-Chyi Chin
1Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, 325 Sec. 2 Cheng-Kung Road, Neihu 114, Taipei, Taiwan, Republic of China.
AJNR. American Journal of Neuroradiology
|March 24, 2004
Summary
Gorham disease, a rare condition causing bone loss, was identified in a man's skull. The study details imaging and pathological findings of this intraosseous angiomatosis.
Area of Science:
- Radiology
- Pathology
- Oncology
Background:
- Gorham disease is a rare, progressive condition involving bone destruction.
- It is characterized by the proliferation of hemangiomatous tissue within bone.
Observation:
- A case of Gorham disease in the left parietal bone of a 23-year-old man is presented.
- Imaging revealed a large skull defect without a soft tissue mass.
Findings:
- Gadolinium-enhanced MRI and Tc-99 m MDP bone scintigraphy showed contrast enhancement and increased isotope uptake at the defect margin.
- Pathological examination confirmed intraosseous angiomatosis at the periphery of the osteolytic lesion.
Implications:
- This case highlights the diagnostic utility of advanced imaging in Gorham disease.
- Understanding the pathological basis is crucial for managing this rare osteolytic condition.