Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mortality and Parkinson disease: A community based study.

Karen Herlofson1, Stein Atle Lie, Dag Arsland

  • 1Departments of Neurology (Drs. Herlofson and Larsen) and Psychiatry (Dr. Arsland), Central Hospital of Rogaland, Stavanger.

Neurology
|March 24, 2004
PubMed
Summary

Parkinson disease (PD) patients exhibit increased mortality compared to the general population, with higher risks observed in younger onset and less definitively diagnosed cases. However, mortality is only modestly elevated in those with definite PD, even with modern treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial-temporal recurrence patterns of grade 4 glioma using deep learning integrated multiparametric MRI and molecular pathology.

NPJ precision oncology·2026
Same author

Effect of periodontal therapy on the oral microbiome and lung function: an intervention study.

Frontiers in cellular and infection microbiology·2026
Same author

Effects of Reducing the Number of Quick Returns (< 11 h off Between Shifts) on Turnover Intention and Job Satisfaction: a Cluster-Randomized Controlled Trial Among Healthcare Workers.

Journal of occupational rehabilitation·2026
Same author

Survey of Norwegian orthodontists on the use of temporary anchorage devices.

BMC oral health·2026
Same author

Validation of the Norwegian version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale.

Clinical parkinsonism & related disorders·2026
Same author

Bivariate GSA-MiXeR: A Novel Tool for Functional Genomic Analyses Implicates Diverse Neural Cell Types for Psychiatric and Neurodegenerative Disorders.

medRxiv : the preprint server for health sciences·2025

Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Parkinson disease (PD) is a neurodegenerative disorder with significant public health implications.
  • Understanding PD patient mortality is crucial for assessing disease burden and treatment efficacy.
  • Previous studies on PD mortality have yielded varied results, necessitating further investigation.

Purpose of the Study:

  • To compare mortality rates in a community-based Parkinson disease cohort with an age-matched general population.
  • To examine the influence of clinical diagnostic certainty and specific features on PD patient survival.
  • To provide updated evidence on Parkinson disease mortality in the context of contemporary medical care.

Main Methods:

  • A cohort of 245 carefully diagnosed Parkinson disease patients was followed for 8 years.

Related Experiment Videos

  • Patients were categorized into definite, probable, and possible PD groups based on clinical criteria.
  • Mortality rates were compared against age- and sex-matched Norwegian population data.

    • Main Results:

    • The overall standardized mortality ratio (SMR) for PD patients was 1.52, indicating a 52% increase in mortality.
    • Increased mortality was observed across both sexes and all age groups at disease onset.
    • Patients with possible PD had a significantly higher SMR (1.99) compared to those with definite PD (1.35).

    Conclusions:

    • This study confirms increased mortality associated with Parkinson disease, even with modern therapeutic approaches.
    • The elevated mortality risk is less pronounced in patients with a high probability of idiopathic PD.
    • Diagnostic accuracy plays a role in survival outcomes for Parkinson disease patients.