Related Experiment Video
Updated: Aug 25, 2026

Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats
Published on: May 27, 2021
Cortical involvement in the generation of "involuntary" movements in restless legs syndrome
Cornelia Rau1, Friedhelm Hummel, Christian Gerloff
1Cortical Physiology Research Group, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany.
Abstract:
The pathophysiology of the restless legs syndrome (RLS) is poorly understood. One index symptom is the urge to move, increasing at night. It is largely accepted that movement in RLS is "involuntary" and that the generators are below the level of the neocortex. Here the authors provide evidence that characteristic leg movements in RLS are preceded by preparatory cortical activation that cannot be attributed to sensory processing or to the expectancy of movement.
Related Concept Videos
REM Sleep Behavior Disorder
RBD is significantly associated with...
Alterations in Muscle Tone lll
Alterations in Muscle Tone ll
Neural Regulation
