Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Small changes in temporal deviance modulate mismatch negativity amplitude in humans.

Michael A Kisley1, Deana B Davalos, Heidi S Layton

  • 1Department of Psychology, University of Colorado at Colorado Springs, 1420 Austin Bluffs Parkway, Colorado Springs, CO 80933-7150, USA. mkisley@uccs.edu

Neuroscience Letters
|March 25, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Malaria among febrile patients during a yellow fever outbreak in Ghana: a cross-sectional study.

Malaria journal·2026
Same author

Assimilation of newly learned category features in the ventromedial prefrontal-anterior hippocampus system.

NeuroImage·2026
Same author

Outbreak of dengue fever in Ghana: The emergence of DENV-1 serotype.

PLoS neglected tropical diseases·2026
Same author

Integrating emotion beliefs and emotion regulation into the pathway from emotional awareness to affective distress.

Emotion (Washington, D.C.)·2026
Same author

Dynamic characteristics of brain networks in patients with obsessive-compulsive disorder based on naturalistic paradigm.

Journal of affective disorders·2026
Same author

Differential associations of cognitive screeners with biological, psychological, and cognitive factors in high-risk older adults.

Journal of Alzheimer's disease : JAD·2026
Same journal

Dynorphinergic neuroadaptations in the islands of Calleja: implications for alcohol use disorder.

Neuroscience letters·2026
Same journal

Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.

Neuroscience letters·2026
Same journal

Role of nNOS/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats.

Neuroscience letters·2026
Same journal

Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulation.

Neuroscience letters·2026
Same journal

Glucocorticoids-induced depressive-like behaviors in mice: oral ingestion of corticosterone or hydrocortisone - A comparative study.

Neuroscience letters·2026
Same journal

Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease.

Neuroscience letters·2026
See all related articles

Mismatch negativity (MMN) amplitude shows sensitivity to subtle temporal changes in stimuli. Even small timing variations significantly increase MMN amplitude, reflecting pre-attentive processing of temporal information.

Area of Science:

  • Neuroscience
  • Auditory Perception
  • Cognitive Psychology

Background:

  • Mismatch negativity (MMN) is a neurophysiological measure reflecting automatic auditory change detection.
  • Previous research has explored MMN sensitivity to various stimulus features, including temporal aspects.

Purpose of the Study:

  • To investigate the sensitivity of mismatch negativity (MMN) amplitude to small temporal (timing) deviations in an auditory stimulus train.
  • To determine the MMN's response within a parameter space representing minimal deviance and narrow variation ranges.

Main Methods:

  • MMN was recorded at the Fz electrode.
  • Stimuli consisted of a 400 ms standard inter-stimulus interval with deviant probabilities of 1/15.
  • Temporal deviance was introduced through decrements of 3.75% to 15% in the inter-stimulus interval.

Related Experiment Videos

Main Results:

  • MMN amplitude significantly increased with increasing degrees of temporal deviance.
  • This sensitivity was observed even within the narrowest tested parameter space of temporal variation.
  • The findings suggest MMN is responsive to subtle temporal changes.

Conclusions:

  • The mismatch negativity (MMN) reflects pre-attentive neural activity sensitive to fine-grained temporal variations.
  • This pre-attentive processing of temporal information may underpin conscious time perception during discrimination tasks.