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The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
Published on: May 17, 2024
[Hypertension and heart disease]
Eva Gerdts1, Per Omvik, Rune Mo
1Institutt for indremedisin, Universitetet i Bergen, 5020 Bergen. eva.gerdts@helse-bergen.no
Insights
Hypertension significantly increases the risk of heart disease, including left ventricular hypertrophy and heart failure. Early detection via echocardiography is crucial for managing these subclinical conditions in hypertensive patients.
Area of Science:
- Cardiology
- Hypertension Research
- Cardiovascular Disease
Context:
- Hypertension is a prevalent condition frequently leading to serious cardiac complications.
- Left ventricular hypertrophy (LVH) and coronary artery disease (CAD) are often subclinical in hypertensive individuals.
- LVH affects a significant portion of hypertensive patients, increasing risks.
Purpose:
- To highlight the link between hypertension and various heart diseases.
- To emphasize the subclinical nature of LVH and CAD in hypertension.
- To underscore the diagnostic and therapeutic role of echocardiography.
Summary:
- Hypertension is a major risk factor for heart disease, including left ventricular hypertrophy (LVH), heart failure, and coronary artery disease (CAD).
- LVH, present in up to 90% of severe hypertension cases, doubles the risk of myocardial infarction, stroke, and sudden death, and quadruples heart failure risk.
- While CAD causes heart failure in men, hypertension is the leading cause in women, with subtle symptoms like fatigue.
Impact:
- Echocardiography can detect subclinical heart disease in hypertensive patients.
- Early diagnosis and treatment guided by echocardiography are essential for managing hypertension-related cardiac conditions.
- Understanding these associations can improve patient outcomes and preventative strategies for cardiovascular disease.
Abstract:
Hypertension commonly leads to heart disease, in particular left ventricular hypertrophy, heart failure and coronary artery disease. Left ventricular hypertrophy and coronary artery disease are both often subclinical diseases in hypertensives. Symptomatic coronary artery disease in hypertension may be due to atherosclerosis in epicardial arteries, microvascular dysfunction, reduced fibrinolytic capacity, or left ventricular hypertrophy; the latter is present in 20-50% of patients with mild to moderate and in up to 90% of patients with severe hypertension. Left ventricular hypertrophy in hypertension is associated with a twofold increase in risk of myocardial infarction, sudden death and stroke, and a fourfold increase in risk of heart failure. While coronary artery disease is the most common cause of heart failure in men, hypertension and in particular untreated isolated systolic hypertension is the most common cause in women. Heart failure symptoms may be subtle in hypertension, like tiredness or reduced physical capacity. Echocardiography can reveal subclinical heart disease as well as serve as a guide to correct diagnosis and treatment.
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