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Updated: Aug 25, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
Published on: June 6, 2017
Cell cycle checkpoints -- molecular background
Barbara Grzelakowska-Sztabert1
1Nencki Institute of Experimental Biology, Warszawa, Poland. b.grzelakowska@nencki.gov.pl
Abstract:
Cell cycle checkpoints are the surveillance mechanisms monitoring both the fidelity and accuracy of DNA replication and the segregation of chromosomes. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication and ensure the proper segregation of chromosomes during mitosis. The paper provides basic information about the molecular mechanisms operating in various cell cycle checkpoints activated by DNA damage or disturbances in mitotic spindle assembly.
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