[Antagonistic effect of sodium ferulate on glycerol-induced renal oxidative injury in mice]
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Published on: May 6, 2018
Zhang-xiu Liao1, Hui Wang, Ren-xiu Peng
1Department of Pharmacology, Medical College, Wuhan University, Wuhan 430071, China.
Aim:
To investigate the effect of sodium ferulate (SF) on glycerol-induced renal injury.
Methods:
Glycerol solution 50% was injected intramuscularly to establish a model of acute tubular necrosis in mice. SF was administered intraperitoneally at the dose of 100-200 mg.kg-1 at the beginning of establishing the model and its effect was observed by monitoring renal function, antioxidative functions and renal pathologic histology.
Results:
At 6 and 72 h after glycerol injection, SF treatment (100-200 mg.kg-1) showed significant and dose-dependent antagonistic actions on the increment of blood urea nitrogen (BUN), creatinine (Cr), and N-acetyl-beta-glucosaminidase (NAG) induced by glycerol. The increase of renal malondialdehyde (MDA) content and the decrease of glutathione content, glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), catalase (Cat) and superoxide dismutase (SOD) activities resulting from glycerol injection were remarkably inversed by SF at the dose of 200 mg.kg-1. Meanwhile, improvement of the renal histology was observed as well.
Conclusion:
SF showed beneficial effect on glycerol-induced acute tubular necrosis due to its antioxidative action.
