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Updated: Aug 25, 2026

Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System
Published on: December 17, 2021
[Unitary-core osmotic pump tablet for controlled release of water-insoluble drug]
Long-xiao Liu1, Qing Xu, Gilson Khang
1College of Pharmaceutical Science, Zhejiang University, Hangzhou 310027, China. liulx@zju.edu.cn
Aim:
To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours.
Methods:
Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied.
Results:
Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release.
Conclusion:
Unitary-core osmotic pump tablet is very easy in preparation and it can deliver water-insoluble drug in substantially constant rate for 24 hours.
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