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Updated: Aug 6, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
[Histoid leprosy with erythema nodosum leprosum]
1Service de Dermatologie, Hôpital Militaire d'instruction Mohammed-V, Rabat, Maroc.
Acta Leprologica
|March 26, 2004
Summary
Histoid leprosy, a rare form of lepromatous leprosy, can develop during dapsone treatment. This case highlights successful treatment with a combination therapy despite erythema nodosum leprosum.
Area of Science:
- Dermatology
- Infectious Diseases
- Microbiology
Background:
- Leprosy is a chronic infectious disease caused by Mycobacterium leprae.
- Lepidermatous leprosy is the most severe form, characterized by widespread skin lesions and nerve damage.
- Histoid leprosy is a rare variant of lepromatous leprosy.
Observation:
- A patient with lepromatous leprosy developed histoid lesions during dapsone monotherapy.
- Histoid lesions presented as nodular and plaque-like growths on seemingly normal skin.
- Histological examination revealed spindle-shaped histiocytes and numerous Mycobacterium leprae.
Findings:
- The patient received treatment according to the national Moroccan protocol.
- Combination therapy including fluoroquinolone, rifampicin, and clofazimine was administered.
- The patient showed a good clinical response to the combination therapy.
Implications:
- This case demonstrates the potential for histoid leprosy to emerge during dapsone treatment.
- Combination therapy can be effective in managing histoid leprosy.
- Erythema nodosum leprosum (ENL) can occur even with effective treatment, requiring careful management.
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