Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Controllable, selective per-functionalization of dendritic oligoamines.

Fritz Vögtle1, Hassan Fakhrnabavi, Oleg Lukin

  • 1Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany. voegtle@uni-bonn.de

Organic Letters
|March 26, 2004
PubMed
Summary

Researchers developed a new method for controlled functionalization of oligoamines using N,N-bis-sulfonylation. This technique allows selective mono- or bis-sulfonylation of amino groups, enabling the synthesis of complex molecular architectures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acyl migrations sensitive to supramolecular encapsulation.

Chemical communications (Cambridge, England)·2025
Same author

Towards Amplified Probing of Weak Intermolecular Interactions on the External Surfaces of Molecular Capsules.

Chemistry (Weinheim an der Bergstrasse, Germany)·2023
Same author

"Geländer" Helical Molecules.

Angewandte Chemie (International ed. in English)·2018
Same author

High-Yielding Rotaxane Synthesis with an Anion Template.

Angewandte Chemie (International ed. in English)·2018
Same author

Dendrimers: From Design to Application-A Progress Report.

Angewandte Chemie (International ed. in English)·2018
Same author

Rational Design of Low Molecular Mass Organogelators: Toward a Library of Functional N-Acyl-1,ω-Amino Acid Derivatives.

Angewandte Chemie (International ed. in English)·2018

Area of Science:

  • Organic Chemistry
  • Polymer Chemistry

Background:

  • Oligoamines are versatile building blocks in synthesis.
  • Controlled functionalization of oligoamines is crucial for creating complex molecular structures.
  • Existing methods for oligoamine functionalization often lack selectivity.

Purpose of the Study:

  • To develop a novel, highly controllable method for functionalizing oligoamines.
  • To achieve selective mono- or bis-sulfonylation of amino groups in oligoamines.
  • To demonstrate the application of this method in synthesizing advanced molecular architectures like dendrimers.

Main Methods:

  • Developed a new N,N-bis-sulfonylation reaction using various sulfonyl chlorides.
  • Investigated the influence of sulfonyl chloride type, base, reaction time, and temperature on selectivity.

Related Experiment Videos

  • Utilized tris(2-aminoethyl)amine as a model compound for detailed procedural investigation.
  • Applied the method to synthesize dumbbell-shaped coupled dendrons and sulfonimide-decorated dendrimers.

    • Main Results:

    • Achieved unprecedented controllable functionalization of oligoamines.
    • Demonstrated selective mono- and bis-sulfonylation of amino groups based on reaction conditions.
    • Successfully synthesized complex structures including dendrons and dendrimers.
    • Established a versatile synthetic route for sulfonimide-containing molecules.

    Conclusions:

    • The developed N,N-bis-sulfonylation method offers precise control over oligoamine functionalization.
    • This methodology provides a powerful tool for constructing sophisticated dendritic architectures.
    • The findings open new avenues for designing functional materials and complex organic molecules.