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Updated: Jul 28, 2026

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Total synthesis of (+/-)-kalihinol C
Ryan D White1, Gregg F Keaney, Corin D Slown
1Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
Abstract:
The total synthesis of kalihinol C, a bis-isonitrile marine diterpenoid isolated from Acanthella sp., is reported. The decalin framework was established via an intramolecular Diels-Alder cycloaddition and subsequently functionalized through a series of substrate-controlled diastereoselective transformations to install the tertiary isonitrile, beta-hydroxy isonitrile, and pendant tetrahydrofuranyl ring.
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