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Updated: Aug 25, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
ATP-conducting maxi-anion channel: a new player in stress-sensory transduction
Ravshan Z Sabirov1, Yasunobu Okada
1Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, 444-8585 Japan. okada@nips.ac.jp
Abstract:
The regulated release of ATP is a fundamental process in cell-to-cell signaling. The electrogenic translocation of ATP via an anion channel has been suggested as one possible mechanism of the release. In this review, we survey possible candidate channels for this pathway. The maxi-anion channel characterized by an exceedingly large unitary conductance has been a stray channel with regard to its function. A newly discovered property, its ATP conductivity and its activation in response to stress signals, indicates that this channel has a central role in stress-sensory transduction for cell volume regulation and tubuloglomerular feedback.
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