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Related Experiment Videos

Experience with cyclosporine.

S Sandrini1, G Setti, N Bossini

  • 1Department of Nephrology, University of Brescia and Spedali Civili, Brescia, Italy. sandrini.silvio@libero.it

Transplantation Proceedings
|March 26, 2004
PubMed
Summary
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Long-term cyclosporine (CsA) use in kidney transplants shows good patient survival but a high chance of increased serum creatinine (sCr). However, this increase is often self-limited, with slow progression and stable renal function in many patients.

Area of Science:

  • Nephrology
  • Immunosuppression
  • Transplantation Medicine

Background:

  • Cyclosporine (CsA) is a cornerstone immunosuppressant in kidney transplantation.
  • Long-term effects of CsA on renal function and graft survival require ongoing evaluation.
  • Understanding factors influencing renal function post-transplant is crucial for patient management.

Purpose of the Study:

  • To assess 15-year renal function and graft survival in cadaveric kidney transplant recipients treated with CsA.
  • To determine the probability of a significant increase in serum creatinine (sCr) and its impact on graft outcomes.
  • To identify predictors of graft deterioration and loss.

Main Methods:

  • Retrospective analysis of 638 cadaveric kidney transplant patients treated with CsA (1983-2001).

Related Experiment Videos

  • Evaluation of renal function, defined by serum creatinine (sCr) levels, at 15 years post-transplant.
  • Multivariate analysis to identify factors associated with graft deterioration.

    • Main Results:

    • At 15 years, patient and graft survival rates were 82.7% and 56.1%, respectively.
    • 53.4% of patients experienced a >30% increase in sCr, with a 74% 15-year probability.
    • Renal function remained stable in 46.6% of patients; graft loss was linked to proteinuria, late acute rejection, and sCr increase extent.

    Conclusions:

    • Long-term CsA therapy is associated with excellent patient and graft survival rates in kidney transplantation.
    • A significant increase in sCr is common but often self-limited, with slow progression observed in many cases.
    • Close monitoring for proteinuria and acute rejection is vital for preserving long-term graft function.