Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclosporine nephrotoxicity.

A Busauschina1, P Schnuelle, F J van der Woude

  • 1Vth Medical Clinic (Nephrology, Endocrinology), University Hospital Mannheim, Medical Faculty of the University of Heidelberg, Mannheim, Germany. aigerim.busauschina@med5.ma.uni-heidelberg.de

Transplantation Proceedings
|March 26, 2004
PubMed
Summary

Cyclosporine (CsA) prevents organ transplant rejection but causes nephrotoxicity. This study explores CsA-induced kidney damage mechanisms and prevention strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carnosinase Gene-Is It Responsible for Diabetic Nephropathy?: Carnosine as a Protective Factor in Diabetic Nephropathy: Association with a Leucine Repeat of the Carnosinase Gene CNDP1. Diabetes 54: 2320-2327, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Dopamine treatment of brain-dead Fisher rats improves renal histology but not early renal function in Lewis recipients after prolonged static cold storage.

Transplantation proceedings·2014
Same author

Reduction of gastrointestinal complications in renal graft recipients after conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium.

Transplantation proceedings·2011
Same author

Modulation of brain dead induced inflammation by vagus nerve stimulation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010
Same author

Imatinib mesylate, a new kid on the block for the treatment of anti-neutrophil cytoplasmic autoantibodies-associated vasculitis?

Clinical and experimental immunology·2008

Area of Science:

  • Nephrology
  • Immunology
  • Pharmacology

Background:

  • Cyclosporine (CsA) is a primary immunosuppressant for solid organ transplantation.
  • CsA use is limited by significant adverse effects, notably nephrotoxicity.

Purpose of the Study:

  • To elucidate the pathomechanisms underlying Cyclosporine-induced nephrotoxicity.
  • To discuss potential strategies for preventing CsA-related kidney damage.

Main Methods:

  • Review of molecular mechanisms of CsA action.
  • Analysis of histological changes associated with CsA nephrotoxicity.
  • Examination of vasoactive substance and gene expression alterations.

Main Results:

  • CsA-induced nephrotoxicity manifests as obliterative vasculopathy and tubulointerstitial fibrosis.

Related Experiment Videos

  • Altered release of angiotensin II, endothelin, prostaglandins, and nitric oxide contribute to damage.
  • Upregulation of transforming growth factor-beta, osteopontin, and collagen I/IV is implicated.

    • Conclusions:

    • Understanding CsA's molecular targets is crucial for managing nephrotoxicity.
    • Targeting specific vasoactive pathways and proliferative genes may offer therapeutic avenues.
    • Prevention strategies are essential to mitigate long-term kidney damage in transplant recipients.