Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Future directions in immunosuppression.

S Beckebaum1, V R Cicinnati, C E Broelsch

  • 1Department of General and Transplant Surgery, University Hospital Essen, Essen, Germany.

Transplantation Proceedings
|March 26, 2004
PubMed
Summary

Cyclosporine (CsA) monitoring using 2-hour postdose concentrations (C2) offers improved precision over trough levels (C0) for optimizing Neoral dosing in liver transplant patients. C2 monitoring may reduce rejection and atherosclerotic risk factors, but long-term data are needed.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Innovative surgical techniques in liver transplantation.

Saudi medical journal·2016
Same author

[Expert recommendations: Hepatitis C and transplantation].

Zeitschrift fur Gastroenterologie·2016
Same author

Renal function at two years in liver transplant patients receiving everolimus: results of a randomized, multicenter study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
Same author

Body weight may not be sufficient for reliable estimation of subcutaneous hepatitis B immunoglobulin dose requirement.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
Same author

Everolimus with reduced tacrolimus in liver transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
Same author

Use of paclitaxel-eluting balloons for endotherapy of anastomotic strictures following liver transplantation.

Endoscopy·2012

Area of Science:

  • Nephrology
  • Immunology
  • Pharmacology

Background:

  • Liver transplantation survival rates are improving, shifting focus to managing long-term complications of immunosuppressants like calcineurin inhibitors.
  • Common complications include diabetes, hypertension, and hyperlipidemia, significantly impacting morbidity and mortality in transplant recipients.
  • Traditional cyclosporine (CsA) monitoring relies on predose trough concentrations (C0).

Purpose of the Study:

  • To evaluate the efficacy of a 2-hour postdose cyclosporine (CsA) monitoring strategy (C2) compared to traditional trough monitoring (C0).
  • To assess the impact of C2 monitoring on optimizing Neoral dosing and patient outcomes in liver transplantation.

Main Methods:

  • Comparison of C2 monitoring strategy against traditional C0 measurements for assessing CsA pharmacokinetics.

Related Experiment Videos

  • Evaluation of Neoral dosing precision and optimization using C2 versus C0.

    • Main Results:

    • C2 monitoring is a more sensitive approach for assessing CsA pharmacokinetics and optimizing Neoral dosing than C0.
    • C2 monitoring is associated with reduced risk factors for atherosclerotic vascular disease.
    • Adoption of C2 monitoring has been linked to a decrease in the incidence and severity of acute cellular rejection.

    Conclusions:

    • C2 monitoring represents a significant advancement over C0 for therapeutic drug monitoring of CsA in liver transplant patients.
    • While C2 monitoring shows promise in reducing complications and rejection, further multicenter trials are necessary to confirm long-term benefits.