Related Experiment Video
Updated: Jan 18, 2026
Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
Published on: November 1, 2024
[Association of reflux esophagitis with Helicobacter pylori]
1Department of Digestive Diseases, First People's Hospital of Foshan City, Foshan 528000, China. chenmantong@163.com
Objective:
To investigate the association of the pathogenesis of reflux esophagitism (RE) with Helicobacter pylori (H. pylori) infection.
Methods:
The prevalences of H. pylori among the patients with RE, normal control subjects, patients with chronic gastritis and patients with duodenal ulcer, as well as the prevalence of H. pylori infection in RE patients of each grade, were compared. Forty patients with endoscopically verified RE grades B or C, along with 20 patients with and another 20 without H. pylori infection were enrolled to receive a 4-week course of rabeprazole treatment, and the subsequent healing rates and symptom relief were compared.
Results:
The prevalences of H. pylori in groups RE, control, chronic gastritis and duodenal ulcer were 30.4%, 28.8%, 59.0% and 91.5% respectively. The rate of H. pylori infection in patients with RE was significantly lower than that in those with chronic gastritis and duodenal ulcer, but was comparable with that in the control subjects. H. pylori infection varied little among RE patients of different grades. In RE patients positive or negative for H. pylori, the healing rates and relief of the symptoms were not different after the treatment.
Conclusion:
H. pylori infection might not be responsible for the susceptibility to RE.
Related Concept Videos
01:29Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
01:30Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
01:22Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...