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Post-prandial plasma ghrelin levels in people with different breakfast hours
1Department of Laboratory Medicine, College of Medicine, Pusan National University, Busan, South Korea.
Objectives:
To investigate the changes in post-meal plasma ghrelin levels in people with different breakfast hours.
Design And Interventions:
The subjects adhered to strict breakfast times starting 2 weeks before the study. Blood was drawn hourly from 0530 or 0630 until 1130. Plasma ghrelin, leptin, and insulin levels were measured by radioimmunoassay.
Setting:
Medical Research Institute, Pusan National University Hospital, Korea.
Subjects:
A total of 16 healthy volunteers.
Results:
The mean plasma ghrelin level in subjects consuming breakfast was 548.7 +/- 239.6 fmol/ml before breakfast and 384.8 +/- 168.7 fmol/ml 1 h after breakfast, with leptin levels of 6.8 +/- 2.6 and 6.5 +/- 2.5 ng/ml, respectively. Plasma ghrelin levels were lowest 1 h after the meal, although the breakfast times differed. The plasma ghrelin level was lowest at 0730 in subjects not eating breakfast.
Conclusions:
These findings suggest that the plasma ghrelin levels are lowest 1 h after breakfast despite the variance in breakfast times. This timing might best reflect an individual's plasma ghrelin level and enable reasonable comparisons.
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