[Efficacy of the Russian anthelmintic agent trichlorophen].

Area of Science:

• Parasitology
• Veterinary Medicine
• Pharmacology

Context:

• Trichocephaliasis caused by Trichocephalus muris and hymenolepiasis caused by Hymenolepis nana are common parasitic infections.
• Murine models (DBA/2st mice and outbred albino mice) are utilized to evaluate anti-parasitic drug efficacy.

Purpose:

• To evaluate the efficacy of specific drug combinations against parasitic infections in mouse models.
• To identify effective treatments for trichocephaliasis and hymenolepiasis.

Summary:

• Micronized trichlorophen combined with albendazole or medamine demonstrated high efficacy against Trichocephalus muris in DBA/2st mice.
• Trichlorophen in combination with azinox or fenasal showed high efficacy against Hymenolepis nana in outbred albino mice.

Impact:

• These drug combinations represent promising therapeutic strategies for human cestodosis and nemadosis.
• The study provides evidence for effective treatment protocols against specific helminth infections.