Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

CD38: a multi-lineage cell activation molecule with a split personality.

F Malavasi¹, A Funaro, M Alessio

¹Dipartimento di Genetica, Biologia e Chimica Medica, Università di Torino e Centro CII/CIOS, CNR, Italy.

International Journal of Clinical & Laboratory Research

|January 1, 1992

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effect of an educational antimicrobial stewardship programme on antibiotic prescriptions' appropriateness in three medical units of a large university hospital: an interrupted time series analysis.

The Journal of hospital infection·2025

Same author

Description of 18 PNH patients with prevalent GPI-deficient monocytes. An Italian survey.

British journal of haematology·2025

Same author

Overview on novel strategies and current guidelines for hematopoietic stem cell mobilisation and collection.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2023

Same author

Increased expression of the ectoenzyme CD38 in peripheral blood plasmablasts and plasma cells of patients with systemic sclerosis.

Frontiers in immunology·2023

Same author

[Cultured platelets].

Bulletin de l'Academie nationale de medecine·2020

Same author

Convalescent plasma, an apheresis research project targeting and motivating the fully recovered COVID 19 patients: A rousing message of clinical benefit to both donors and recipients alike.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2020

Same journal

Lack of association of fibrinogen, lipoprotein(a), and albumin excretion rate with low birthweight.

International journal of clinical & laboratory research·2001

Same journal

Assay of erythrocyte membrane fatty acids. Effects of storage time at low temperature.

International journal of clinical & laboratory research·2001

Same journal

Bovine seminal RNase induces apoptosis in normal proliferating lymphocytes.

International journal of clinical & laboratory research·2001

Same journal

Cigarette smoking as an aggravating factor in inflammatory tissue-destructive diseases. Increase in tumor necrosis Factor-alpha priming of peripheral neutrophils measured as generation of oxygen radicals.

International journal of clinical & laboratory research·2001

Same journal

Angiotensin converting enzyme DD genotype affects the changes of plasma plasminogen activator inhibitor-1 activity after primary percutaneous transluminal coronary angioplasty in acute myocardial infarction patients.

International journal of clinical & laboratory research·2001

Same journal

Antigastric autoantibodies in Helicobacter pylori infection: role in gastric mucosal inflammation.

International journal of clinical & laboratory research·2001

See all related articles

This review details the human surface molecule CD38, crucial for cell signaling and immune responses. Research explores its structure, function, and potential ligand interactions for a deeper understanding of its role in cell activation.

Area of Science:

Immunology
Cell Biology

Background:

CD38 is a cell surface molecule expressed on various immune cells.
Its precise in vivo function and natural ligand remain largely unknown.

Purpose of the Study:

To review the characteristics of the human CD38 molecule.
To discuss its role in cell signaling and activation.
To highlight areas of ongoing research regarding its in vivo function.

Main Methods:

Review of existing literature on CD38.
Analysis of CD38 structure and expression patterns.
Discussion of studies utilizing transfectant cell models.

Main Results:

CD38 is a 46 kDa single-chain transmembrane molecule.

Related Experiment Videos

It is involved in signal transduction for cell activation and proliferation.

Expressed predominantly on early and activated phenotypes, independent of cell lineage.

Conclusions:

CD38 plays a significant role in immune cell activation and proliferation.
Further research is needed to elucidate its in vivo function, natural ligand, and population polymorphism.