Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

L-deaza-5'-noraisteromycin.

Xueqiang Yin1, Stewart W Schneller

  • 1Department of Chemistry, Auburn University, Auburn, Alabama 36849, USA.

Nucleosides, Nucleotides & Nucleic Acids
|March 27, 2004
PubMed
Summary

Researchers explored 1-deaza-5'-noraristeromycin derivatives as potential antiviral drugs. These compounds showed no antiviral activity or cytotoxicity against a broad range of viruses tested.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

2- and 3-Fluoro-3-deaza-1',6'-isoneplanocin: Synthesis and antiviral properties (including Ebola and Marburg).

Bioorganic & medicinal chemistry letters·2023
Same author

Mechanisms of anti-vesicular stomatitis virus activity of deazaneplanocin and its 3-brominated analogs.

Antiviral research·2021
Same author

Enantiomeric 4'-truncated 6'-fluoro-3-deazaneplanocin and its 3-bromo derivative: Synthesis and antiviral properties, including Ebola and Marburg.

Bioorganic & medicinal chemistry letters·2021
Same author

5'-Nor-3-Deaza-1',6'-Isoneplanocin, the Synthesis and Antiviral Study.

Molecules (Basel, Switzerland)·2020
Same author

Enantiomeric 4'-Truncated 3-deaza-1',6'-isoneplanocins: Synthesis and antiviral properties including Ebola.

Bioorganic & medicinal chemistry letters·2019
Same author

6'-Fluoro-3-deazaneplanocin: Synthesis and antiviral properties, including Ebola.

Bioorganic & medicinal chemistry letters·2018

Area of Science:

  • Medicinal Chemistry
  • Virology
  • Biochemistry

Background:

  • S-adenosylhomocysteine (AdoHcy) hydrolase is a target for antiviral drug development.
  • Inhibitors of AdoHcy hydrolase can affect S-adenosylmethionine (AdoMet)-dependent biomethylations.
  • (+/-)-1-Deazaaristeromycin is a known inactivator of AdoHcy hydrolase.

Purpose of the Study:

  • To synthesize and evaluate enantiomers of 1-deaza-5 ominoaristeromycin as potential antiviral agents.
  • To investigate their inhibitory effects on S-adenosylhomocysteine hydrolase.
  • To assess their activity against a wide spectrum of viruses.

Main Methods:

  • Synthesis of both enantiomers of 1-deaza-5 ominoaristeromycin.
  • Antiviral screening against 24 different viruses.
  • Cytotoxicity assays on viral host cells.

Main Results:

  • The synthesized compounds, 1-deaza-5 ominoaristeromycin enantiomers (5 and 20), were prepared.
  • No antiviral activity was observed against any of the tested viruses.
  • No cytotoxicity was detected in the viral host cells.

Conclusions:

  • 1-Deaza-5 ominoaristeromycin derivatives are not effective antiviral agents.
  • These compounds do not exhibit significant cytotoxicity, suggesting a favorable safety profile.
  • Further research may be needed to explore other derivatives or mechanisms.

Related Experiment Videos