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Updated: Aug 25, 2026
15:22
Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Biologically active antisense phosphorothioate oligodeoxyribonucleotides: synthesis, characterization, and studies of
Vasulinga T Ravikumar1, Walt F Lima, Kent Van Sooy
1Isis Pharmaceuticals, Carlsbad, California 92008, USA. vravikumar@isisph.com
Nucleosides, Nucleotides & Nucleic Acids
|March 27, 2004
Abstract:
Multiple phosphorothioate oligonucleotides containing a 3'-terminal negative charge were synthesized and characterized. Influence of the added negative charge on activation of duplexes by RNase H was investigated. No additional help in recruitment of RNase H was observed.
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