Synthesis of 2'-substituted MMI linked nucleosidic dimers: an optimization study in search of high affinity
Didier Peoc'h1, Eric E Swayze, Balkrishen Bhat
1Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc., Carlsbad, California 92008, USA.
Nucleosides, Nucleotides & Nucleic Acids
|March 27, 2004
Abstract:
The synthesis of a series of methylene(methylimino) (MMI) linked oligodeoxyribonucleotide dimers modified at the 2'-position with fluoro and/or methoxy groups and their incorporation into different sequences has been accomplished. From these dimers, bis 2'-OMe MMI dimer was selected for further studies based on its synthetic accessibility and the increased thermodynamic stability conferred upon oligonucleotides incorporating this modification.
