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Leiomyosarcoma of the kidney: a clinicopathologic study
Andrea T Deyrup1, Elizabeth Montgomery, Cyril Fisher
1Department of Pathology, University of Chicago, Chicago, IL, USA.
The American Journal of Surgical Pathology
|March 27, 2004
Summary
Renal leiomyosarcoma is rare, with most cases being intermediate or high grade. These aggressive tumors often lead to metastasis and a poor prognosis, highlighting the need for further research.
Area of Science:
- Oncology
- Pathology
- Urologic Oncology
Background:
- Renal leiomyosarcoma is an exceptionally rare kidney tumor.
- Limited clinical data exists for this rare entity.
Purpose of the Study:
- To review and characterize renal leiomyosarcoma cases.
- To analyze immunohistochemical profiles and clinical outcomes.
- To correlate tumor grade with patient prognosis.
Main Methods:
- Retrospective review of renal leiomyosarcoma cases from three institutions.
- Immunohistochemical staining for smooth muscle markers, epithelial markers, cytokeratin, and S-100 protein.
- Clinical follow-up data collection and analysis.
Main Results:
- Immunohistochemistry confirmed smooth muscle origin (positive for smooth muscle actin, desmin, calponin, h-caldesmon).
- Epithelial membrane antigen was positive in one case; cytokeratin and S-100 protein were negative.
- Of 9 patients with follow-up, 5 died of disease, 2 were alive with no evidence of disease, and 2 were alive with disease.
- Higher tumor grade correlated with poorer outcomes; all grade 3 tumors were fatal.
Conclusions:
- Renal leiomyosarcomas are typically intermediate or high grade.
- These tumors carry a poor prognosis, often associated with metastasis and disease-related death.
- Tumor grade is a significant prognostic factor in renal leiomyosarcoma.