Related Experiment Video
Updated: Aug 25, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Phenolic metabolites of Dalea versicolor that enhance antibiotic activity against model pathogenic bacteria
Gil Belofsky1, Diamond Percivill, Kim Lewis
1Department of Chemistry and Biochemistry, The University of Tulsa, Tulsa, Oklahoma 74101, USA.
Abstract:
A new flavonoid (1) was isolated from organic extracts of Dalea versicolor, along with six known phenolic compounds (2-7). The structures of the seven compounds were determined by NMR and HRMS methods. These compounds were evaluated for direct activity against a variety of organisms in vitro, including the Gram-positive bacteria Staphylococcus aureus and Bacillus cereus. In addition, the compounds were evaluated for their ability to potentiate the activity of known antimicrobials through inhibition of multidrug-resistance (MDR) pumps. Compounds 1, 2, 4, and 7 exhibited direct or synergistic activity toward the human pathogen S. aureus and the opportunistic pathogen B. cereus. Compounds 4 and 7 were also found to potentiate the activity of berberine and of prescribed antibiotics, with 4 demonstrating a mode of action consistent with inhibition of the NorA MDR efflux pump in S. aureus.
Related Concept Videos
Antifungal Agents
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Antimicrobial Effectiveness
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Gene Regulation in Microbial Communities: Quorum Sensing
Production of Antibiotics