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New nitrogenous Germacranes from a Thai marine sponge, Axinyssa n. sp
Veena Satitpatipan1, Khanit Suwanborirux
1Bioactive Marine Natural Products Chemistry Research Unit (BMNCU), Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
Journal of Natural Products
|March 27, 2004
Abstract:
Two new germacrane sesquiterpenes, including (1Z,4Z)-7alphaH-11-aminogermacra-1(10),4-diene (1) and N,N'-11-bis[(1Z,4Z)-7alphaH-germacra-1(10),4-dienyl]urea (2), were isolated from a Thai marine sponge Axinyssan. sp. collected from the Andaman Sea. The structure elucidations of 1 and 2 were accomplished by means of 1D and 2D NMR, MS, and IR spectroscopy. Only 1 exhibited strong antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Candida albicans.