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Organ weights in nonagenarians.

T H Howell

    Journal of the American Geriatrics Society
    |September 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Organ weights in nonagenarians show significant changes with aging. While brains, livers, kidneys, lungs, and spleens typically decrease in weight, hearts often enlarge and become hypertrophied in advanced age.

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    Area of Science:

    • Gerontology
    • Pathology
    • Human Anatomy

    Background:

    • Aging is associated with physiological changes in organ systems.
    • Understanding organ weight variations in the elderly is crucial for geriatric medicine.

    Purpose of the Study:

    • To document and analyze the organ weights of nonagenarians (individuals aged 90 and above).
    • To compare organ weights in nonagenarians with those of younger subjects.

    Main Methods:

    • Autopsy was performed on 39 nonagenarian subjects.
    • Weights of major organs including the brain, liver, spleen, kidneys, lungs, and heart were meticulously recorded.

    Main Results:

    • Significant individual variability in organ weights was observed among nonagenarians.

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  • The majority of nonagenarians exhibited reduced weights in brains, livers, spleens, kidneys, and lungs compared to younger individuals.
  • A notable finding was the increased weight and frequent hypertrophy of the heart in many nonagenarian subjects.

    • Conclusions:

    • Organ weight changes, including atrophy of some organs and cardiac hypertrophy, are characteristic of advanced aging.
    • These findings highlight the impact of extreme longevity on organ morphology and function.