Related Experiment Video
Updated: Aug 25, 2026

A Thermoplasmonic Approach for Investigating Plasma Membrane Repair in Living Cells and Model Membranes
Published on: January 19, 2024
Identification of a novel class of annexin genes
Vahid Khalaj1, Lyndsay Smith, Jayne Brookman
1F2G Ltd., P.O. Box 1, Lankro Way, Eccles, Manchester M30 0BH, UK.
Abstract:
The annexins are a family of calcium- and phospholipid-binding proteins that have been widely studied in animals. Investigation of annexins in the fungus Aspergillus fumigatus identified a novel annexin-like gene (ANXC4) as well as two conventional annexins (ANXC3.1 and ANXC3.2). The genes were initially identified by bioinformatics, and sequences were then determined experimentally. Reverse transcription polymerase chain reaction indicated that all three genes were expressed. ANXC4 lacked calcium-binding consensus sequences and had a 553 residue N-terminal tail. However, bioinformatics indicated that ANXC4 is an annexin and homologues were identified in other filamentous fungi. ANXC4 therefore represents a new grouping within the annexin family.
More Related Videos
10:41Using a GFP-tagged TMEM184A Construct for Confirmation of Heparin Receptor Identity
Published on: February 17, 2017
12:15The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analysis and Imaging
Published on: October 3, 2017
Related Concept Videos
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Gap Junctions
Genome Size and the Evolution of New Genes
Cytoskeletal Linker Proteins - Plakins
Cytoskeletal Accessory Proteins