Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Novel neuronal phenotypes from neural progenitor cells.

Eleni A Markakis1, Theo D Palmer, Lynne Randolph-Moore

  • 1Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|March 27, 2004
PubMed
Summary

Researchers isolated progenitor cells from the hypothalamus, revealing their potential to generate diverse neuroendocrine neurons in vitro. This finding highlights the plasticity of neural precursors and expands the known phenotypes of hypothalamic neurons.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impaired lipoprotein secretion by APOE4 leads to lysosomal and mitochondrial dysfunction in human microglia.

bioRxiv : the preprint server for biology·2026
Same author

Aberrant CD4<sup>+</sup> T cell refeeding response impairs neuro-immune crosstalk in Parkinson's disease.

bioRxiv : the preprint server for biology·2026
Same author

Scalable longitudinal imaging and transcriptomics of cells in dynamic enclosures.

bioRxiv : the preprint server for biology·2026
Same author

RUNX1 and YY1 modulate neuronal fate and energy metabolism in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same author

CK2 inhibition suppresses glial inflammation in models of neuroinflammation and neurodegeneration.

Nature communications·2026
Same author

DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons.

bioRxiv : the preprint server for biology·2026

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Research

Background:

  • The hypothalamus, a basal plate derivative, typically ceases postnatal neurogenesis.
  • The hippocampus, an alar plate derivative, retains neurogenic potential into adulthood.
  • Brain regions contain distinct cell categories influencing neuronal development.

Purpose of the Study:

  • To investigate the neurogenic potential of hypothalamic progenitor cells.
  • To compare hypothalamic and hippocampal progenitor cell differentiation.
  • To explore the generation of neuroendocrine phenotypes from neural precursors.

Main Methods:

  • Isolation of progenitor cells from rat hypothalamus and hippocampus.
  • Culture of neural progenitor cells in vitro.

Related Experiment Videos

  • Analysis of differentiated neuronal phenotypes, including neuropeptides.

    • Main Results:

    • Hypothalamic progenitor cells generated neuropeptide-expressing neurons in vitro.
    • Both hypothalamic and hippocampal progenitor cultures produced indistinguishable neuronal populations.
    • In vitro culture induced plasticity, enabling the generation of diverse neuronal phenotypes.

    Conclusions:

    • Cultured hypothalamic neural precursors exhibit significant plasticity, generating various neuronal phenotypes.
    • This study demonstrates the potential for in vitro generation of neuroendocrine neurons from hypothalamic progenitors.
    • Short-term culture can overcome in vivo environmental constraints on neuronal differentiation.