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Novel model peptide for Atx1-like metallochaperones
Olivier Sénèque1, Serge Crouzy, Didier Boturyn
1Laboratoire de Reconnaissance Ionique, SCIB, CEA/DSM/DRFMC, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
Chemical Communications (Cambridge, England)
|March 27, 2004
Abstract:
The novel cyclodecapeptide c(GMTCSGCSRP) is able to bind soft metals with a selectivity for Hg(2+) and Cu(+) over Pb(2+), Cd(2+) and Zn(2+), and is demonstrated to be an excellent structural model of the binding loop of the copper metallochaperone Atx1 in its apo and mercury loaded forms.