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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

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Clear cell sarcoma arising from the chest wall: a case report.

Yoshiyuki Suehara¹, Yasuo Yazawa, Kouhei Hitachi

¹Department of Orthopedic Oncology, Tochigi Cancer Center, 4-9-13 Younan, Utsunomiya 320-0834, Japan.

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association

|March 27, 2004

Summary

Clear cell sarcoma, a rare soft tissue cancer, can occur in the chest wall. This case highlights successful treatment with chemotherapy and surgical resection for chest wall clear cell sarcoma.

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Area of Science:

Oncology
Pathology
Surgical Oncology

Background:

Clear cell sarcoma is a rare, aggressive soft tissue neoplasm typically found near tendons and aponeuroses.
While most commonly affecting extremities, it can rarely present in the trunk.

Observation:

A case report details a 20-year-old woman with a 2-year history of chest wall mass and pain.
Biopsy revealed nests of round cells with clear cytoplasm, confirmed as clear cell sarcoma via S-100 and HMB-45 immunohistochemistry.

Findings:

The patient received neoadjuvant chemotherapy with ifosfamide, carboplatin, and etoposide.
Wide-margin surgical resection of the chest wall tumor, sternum, and adjacent tissues was performed.
Reconstruction involved Marlex mesh, regin, and a musculocutaneous flap.

Implications:

This case demonstrates the successful management of a rare chest wall clear cell sarcoma.
Multimodal treatment including chemotherapy and extensive surgery can achieve favorable outcomes.
Further research into optimal treatment strategies for extrimity clear cell sarcoma is warranted.