Related Experiment Video

Updated: Aug 25, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

[Nervous system involvement in children suffering from disorders associated with vasculitis]

Marek Kaciński1, Grazyna Gucwa-Piotrowska, Alicja Kubik

  • 1Klinika Neurologii Dzieciecej, Wydział Lekarski Collegium Medicum, Uniwersytet Jagielloński, ul. Wielicka 265, 30-663 Kraków. neupedkr@cm-uj.krakow.pl

Neurologia I Neurochirurgia Polska
|March 30, 2004
PubMed

Insights

This study examines vasculitis affecting the nervous system in 12 children, with a focus on central nervous system (CNS) and peripheral nervous system involvement. Ischaemic stroke was the most common presentation, highlighting key diagnostic and therapeutic challenges.

Area of Science:

  • Pediatric Neurology
  • Rheumatology
  • Neuroscience

Context:

  • Vasculitis encompasses a group of disorders characterized by inflammation of blood vessel walls.
  • Neurological involvement in pediatric vasculitis presents unique diagnostic and management challenges.
  • This study focuses on a cohort of pediatric patients with nervous system vasculitis.

Purpose:

  • To describe the clinical characteristics, diagnostic approaches, and therapeutic strategies for pediatric vasculitis involving the nervous system.
  • To identify the most frequent neurological manifestations and etiological factors in this patient group.
  • To discuss the developmental, diagnostic, etiopathogenetic, and therapeutic aspects specific to childhood nervous system vasculitis.

Summary:

  • The study analyzed 12 pediatric patients diagnosed with vasculitis affecting the nervous system.
  • Eight patients had central nervous system (CNS) involvement, while four had peripheral nervous system (PNS) involvement.
  • Ischaemic stroke was identified as the most prevalent clinical presentation among the studied cases.

Impact:

  • Provides insights into the epidemiology and clinical spectrum of nervous system vasculitis in children.
  • Highlights the importance of early diagnosis and tailored treatment for improving outcomes.
  • Contributes to the understanding of etiopathogenesis and informs future research directions in pediatric vasculitis.

Related Concept Videos

Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
The Parasympathetic Nervous System01:14

The Parasympathetic Nervous System

Overview
Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...