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[Gastrointestinal stromal tumor].

Toshirou Nishida1, Takeshi Ohmori, Hikaru Matsuda

  • 1Dept. of Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|March 30, 2004
PubMed
Summary

Gastrointestinal stromal tumors (GISTs) are common gut tumors driven by KIT mutations. While imatinib is a key treatment, resistance can develop over time.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Gastroenterology

Context:

  • Gastrointestinal stromal tumors (GISTs) are the most common submucosal tumors of the gastrointestinal tract.
  • GISTs are characterized by the expression of the KIT protein.
  • Oncogenesis and tumor growth are driven by gain-of-function mutations in the KIT or PDGF-R alpha gene.

Purpose:

  • To discuss the role of imatinib mesylate in treating non-resectable GISTs.
  • To highlight the clinical efficacy and tolerability of imatinib.
  • To acknowledge the emergence of imatinib resistance after prolonged use.

Summary:

  • Surgery is the primary treatment for resectable GISTs.
  • Imatinib mesylate, a targeted therapy, demonstrates significant clinical benefits and good tolerability for non-resectable GISTs.
  • Despite its effectiveness, acquired resistance to imatinib is a clinical challenge in long-term GIST management.

Impact:

  • Imatinib has become a first-line therapy for non-resectable GISTs.
  • Understanding imatinib resistance is crucial for developing subsequent treatment strategies.
  • This highlights the need for ongoing research into alternative therapies and resistance mechanisms for GIST patients.

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