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[Ewing's sarcoma].

Takahiro Goto1, Takahiro Hozumi, Taiji Kondo

  • 1Dept. of Orthopaedic Surgery and Musculoskeletal Oncology, Tokyo Metropolitan Komagome Hospital, 3-18-22 Hon-Komagome, Bunkyo-ku, Tokyo 113-8677, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|March 30, 2004
PubMed
Summary

Ewing's sarcoma is a high-grade bone malignancy in children, characterized by pain and swelling. Treatment involves a multimodal approach including chemotherapy, surgery, and radiotherapy for optimal outcomes.

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Area of Science:

  • Pediatric Oncology
  • Skeletal Malignancies

Context:

  • Ewing's sarcoma represents 6.8% of primary malignant bone tumors.
  • Primarily affects children aged 5-15 years.
  • Characterized by pain, swelling, and elevated inflammatory markers.

Purpose:

  • To provide a comprehensive overview of Ewing's sarcoma.
  • To detail diagnostic imaging and histological features.
  • To outline current treatment strategies and emerging therapies.

Summary:

  • Radiological findings include permeative bone destruction and periosteal reaction.
  • Histology reveals sheets of small round cells with glycogen granules.
  • Immunohistochemistry shows positivity for vimentin and CD99.
  • Genetic analysis identifies the EWS/FLI-1 fusion gene in t(11;22) translocation.

Impact:

  • Multimodal treatment combining chemotherapy, surgery, and radiotherapy is standard.
  • Neoadjuvant chemotherapy reduces tumor volume and eradicates micrometastasis.
  • High-dose chemotherapy with autologous bone marrow transplantation shows promise for poor-prognosis cases.

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