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Published on: August 29, 2015
Physiological functions of protein kinase B/Akt
Z-Z Yang1, O Tschopp, A Baudry
1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
Biochemical Society Transactions
|March 30, 2004
Summary
Genetic manipulation in mice provides insights into protein functions. This study examines phenotypes of protein kinase B (PKB)/Akt overexpression and mutant mice to understand PKB/Akt roles in mammals.
Area of Science:
- Physiology
- Genetics
- Molecular Biology
Background:
- Genetic manipulation of mice is crucial for studying protein function and validating cell culture findings.
- Recent advancements include the development of various transgenic and knockout mouse models for protein kinase B (PKB)/Akt.
Purpose of the Study:
- To elucidate the physiological functions of PKB/Akt in mammals.
- To analyze the phenotypes of PKB/Akt overexpression and mutant mouse models.
Main Methods:
- Generation of transgenic mouse models.
- Generation of knockout mouse models.
- Phenotypic analysis of genetically modified mice.
Main Results:
- Overexpression of PKB/Akt in mice leads to observable phenotypic changes.
- Mutant PKB/Akt mouse models exhibit distinct phenotypes.
- These phenotypes provide insights into PKB/Akt-mediated biological processes.
Conclusions:
- PKB/Akt plays a significant role in mammalian physiology.
- Mouse models are valuable tools for dissecting complex protein functions.
- Further research on PKB/Akt phenotypes can uncover novel therapeutic targets.
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