Changes in body composition during hormonal therapy for prostate cancer

Area of Science:

• Endocrinology
• Oncology
• Sports Medicine

Background:

• Androgens significantly influence male body composition.
• Androgen-deprivation therapy (ADT) is a primary treatment for advanced prostate cancer.
• ADT can lead to detrimental changes in body composition, including increased fat mass and reduced lean body mass.

Purpose of the Study:

• To highlight the adverse body composition changes associated with androgen-deprivation therapy.
• To discuss the potential health consequences of these body composition changes.
• To explore strategies for managing or preventing these effects.

Main Methods:

• Review of existing literature on androgen effects and ADT outcomes.
• Analysis of the physiological impact of reduced androgen levels.
• Identification of potential therapeutic interventions.

Main Results:

• ADT is linked to increased adiposity and decreased muscle mass in men.
• These body composition alterations may contribute to fatigue, bone fractures, insulin resistance, and cardiovascular risks.
• Exercise, alternative hormonal treatments, and insulin-sensitizing agents are potential countermeasures.

Conclusions:

• Adverse body composition changes are a significant concern during androgen-deprivation therapy for prostate cancer.
• These changes have wide-ranging negative health implications.
• Proactive management strategies, including exercise and pharmacological interventions, are crucial for patient well-being.