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Updated: Aug 25, 2026

Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons
Published on: November 20, 2018
Interneuron Diversity series: Circuit complexity and axon wiring economy of cortical interneurons
György Buzsáki1, Caroline Geisler, Darrell A Henze
1Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA.
Abstract:
The performance of the brain is constrained by wiring length and maintenance costs. The apparently inverse relationship between number of neurons in the various interneuron classes and the spatial extent of their axon trees suggests a mathematically definable organization, reminiscent of 'small-world' or scale-free networks observed in other complex systems. The wiring-economy-based classification of cortical inhibitory interneurons is supported by the distinct physiological patterns of class members in the intact brain. The complex wiring of diverse interneuron classes could represent an economic solution for supporting global synchrony and oscillations at multiple timescales with minimum axon length.
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