Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function.

Robert D Burgoyne1, Dermott W O'Callaghan, Burcu Hasdemir

  • 1The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK. burgoyne@liverpool.ac.uk

Trends in Neurosciences
|March 30, 2004
PubMed
Summary

Neuronal Ca2+-sensor (NCS) proteins and Ca2+-binding proteins (CaBPs) are crucial for neuronal function. These proteins regulate gene expression, ion channels, and apoptosis by sensing distinct Ca2+ signals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deletion of the WD40 domain of ATG16L1 exacerbates acute pancreatitis, abolishes LAP-like non-canonical autophagy and slows trypsin degradation.

Autophagy·2024
Same author

Neighbourhood Watch: Two-pore-2 channels talking to IP3 receptors.

Cell calcium·2024
Same author

Lysosome exocytosis is required for mitosis in mammalian cells.

Biochemical and biophysical research communications·2022
Same author

Mitosis, Focus on Calcium.

Frontiers in physiology·2022
Same author

CPVT-associated calmodulin variants N53I and A102V dysregulate Ca2+ signalling via different mechanisms.

Journal of cell science·2021
Same author

Polarity of action in salivary gland acinar cells: Local and preferential Ca<sup>2+</sup> signalling.

Cell calcium·2021

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Neuronal activity relies heavily on calcium (Ca2+) signals.
  • Ca2+-sensor proteins, including EF-hand-containing Ca2+-binding proteins, are essential for transducing these signals.
  • The neuronal Ca2+ sensor (NCS) protein family and related Ca2+-binding proteins (CaBPs) are increasingly recognized for their critical roles in neurons.

Purpose of the Study:

  • To highlight the significance of NCS proteins and CaBPs in neuronal function.
  • To explore how these proteins discriminate between different Ca2+ signal patterns.
  • To summarize the established physiological roles of NCS proteins and CaBPs.

Main Methods:

  • Literature review of recent research on NCS proteins and CaBPs.

Related Experiment Videos

  • Analysis of protein expression patterns in neuronal tissues.
  • Investigation of protein-membrane interactions in response to Ca2+.
  • Review of studies detailing physiological functions.

    • Main Results:

    • NCS proteins and CaBPs are predominantly expressed in neurons, often with cell-specific patterns.
    • Their membrane association capabilities enable discrimination of spatial and temporal Ca2+ signals.
    • These proteins play roles in gene expression, ion channel function, membrane trafficking, and apoptosis control.

    Conclusions:

    • NCS proteins and CaBPs are vital regulators of neuronal activity.
    • Their ability to sense and respond to Ca2+ signals underpins diverse cellular processes.
    • Further research into these proteins will illuminate fundamental aspects of neuronal function.