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Processing, annealing and sterilisation of poly-L-lactide
N A Weir1, F J Buchanan, J F Orr
1School of Mechanical and Manufacturing Engineering, Queen's University Belfast, Ashby Building, Stranmillis Road, Belfast BT9 5AH, UK. n.weir@qub.ac.uk
Biomaterials
|March 30, 2004
Summary
Processing and sterilization significantly alter Poly-L-lactide (PLLA) properties. These changes impact PLLA
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Materials Engineering
Background:
- Poly-L-lactide (PLLA) is a key bioabsorbable polymer.
- Its degradation rate is influenced by molecular weight and crystallinity.
Purpose of the Study:
- To assess the impact of processing and sterilization on PLLA properties.
- To understand how these methods affect molecular weight, crystallinity, and mechanical characteristics.
Main Methods:
- PLLA pellets were compression molded and extruded.
- Materials underwent annealing and ethylene oxide (EtO) sterilization.
- Mechanical properties, molecular weight, and crystallinity were measured.
Main Results:
- Processing reduced initial crystallinity; annealing and EtO sterilization increased it.
- A slight decrease in molecular weight was observed after processing and sterilization.
- Increased crystallinity correlated with higher Young's modulus and lower tensile strength/extension at break.
Conclusions:
- PLLA's critical properties are sensitive to processing and sterilization methods.
- These alterations can significantly affect the degradation rate of PLLA devices.