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Temporary vascular occlusion with poloxamer 407
Jean Raymond1, Annick Metcalfe, Igor Salazkin
1Interventional Neuroradiology Laboratory, CHUM Research Center, Notre-Dame Hospital, Mailloux Pavilion M-8206, 1560 Sherbrooke East, Montreal, Que., Canada H2L 4M1. dr_jean_raymond@hotmail.com
Biomaterials
|March 30, 2004
Summary
Poloxamer 407, a safe polymer, demonstrated effective temporary occlusion in endovascular procedures. It showed rapid reversible sol-gel transition, dissolving within hours without causing lasting pathological changes.
Area of Science:
- Biomaterials Science
- Interventional Radiology
- Polymer Chemistry
Background:
- Percutaneous endovascular procedures require safe and reversible occlusion methods.
- Poloxamer 407, a non-ionic surfactant, exhibits rapid reversible sol-gel transition properties.
Purpose of the Study:
- To investigate the safety and efficacy of Poloxamer 407 as a temporary embolic agent for endovascular procedures.
Main Methods:
- In vitro determination of Poloxamer 407 dissolution time after gelation.
- In vivo transient occlusion of renal and pulmonary arteries in dogs, followed by serial angiograms.
- Macroscopic and pathological examination 1 week post-occlusion, with additional studies in pigs and rabbits.
Main Results:
- In vitro dissolution occurred within 1-20 hours, concentration-dependent.
- In vivo 22% Poloxamer 407 injections achieved complete occlusion with full recanalization in 10-90 minutes.
- No pathological abnormalities were observed at 1 week; transient triglyceride elevation was the only biochemical effect.
Conclusions:
- Poloxamer 407 is a safe and effective embolic material for temporary occlusions in endovascular interventions.
- The polymer's reversible nature and lack of long-term adverse effects support its potential clinical use.