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Updated: Aug 25, 2026

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
Published on: April 11, 2011
HLA-Ig-based artificial antigen-presenting cells: setting the terms of engagement
Mathias Oelke1, Jonathan P Schneck
1Department of Pathology and Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. bmpe5@cs.com
Abstract:
Recent advances in molecular medicine have shown that soluble MHC-multimers can be valuable tools for both the stimulation of as well as the analysis of antigen-specific T cells in vitro. In this review, we describe the use of dimeric major histocompatibility complexes, HLA-Ig, to visualize antigen-specific T cells as well as their potential to stimulate immune responses as part of an artificial antigen-presenting cell (aAPC). The use of HLA-Ig-based aAPC represents an exciting new approach to generate antigen-specific CTL for adoptive immunotherapy that helps to overcome many of the obstacles associated with limitations in current approaches to adoptive immunotherapy.
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