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Expression of the inhibin-alpha subunit in normal, hyperplastic and malignant endometrial tissue: an
Ioannis Mylonas1, Josef Makovitzky, Dagmar-Ulrike Richter
1Department of Obstetrics and Gynecology, University of Rostock, Rostock, Germany.
Objectives:
Determination of the frequency and tissue distribution of inhibin-alpha (INH-alpha) in normal, hyperplastic and malignant endometrium.
Materials And Methods:
Endometrial tissue was obtained from normal, hyperplastic (glandular-cystic hyperplasia), adenomatous hyperplasia (AH grade I to III) and endometroid adenocarcinoma and immunohistochemically characterized with INH-alpha antibody.
Results:
INH-alpha was expressed in normal, hyperplastic and malignant endometrium. Highest expression was observed during secretory phase and glandular-cystic hyperplasia compared to all groups. A continuous decline was noted from AH grade I to III with a significance between AH I and II.
Discussion:
A menstrual cycle associated expression of INH-alpha in glandular endometrial epithelium was observed. Since AH grade II and III can be considered as a precursor of endometrial cancer, INH-alpha could be a marker of cell transformation and an endometrial tumor-suppressor agent.
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