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A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
Published on: November 1, 2013
Reduced triclosan susceptibility in methicillin-resistant Staphylococcus epidermidis
Molly B Schmid1, Nachum Kaplan
1Affinium Pharmaceuticals, Inc., Toronto, Ontario M5J 1V6, Canada.
Abstract:
Triclosan MIC determination showed that recent Staphylococcus aureus clinical isolates (n = 100) were highly susceptible to triclosan, with a 50% minimal inhibitory concentration (MIC(50)) of 0.12 microg/ml and a MIC(90) of 0.25 microg/ml. Staphylococcus epidermidis isolates (n = 96) were less susceptible, with a MIC(50) of 0.12 microg/ml and a MIC(90) of 8 microg/ml. Decreased susceptibility to triclosan was more prevalent among methicillin-resistant S. epidermidis than among methicillin-sensitive S. epidermidis isolates.
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